[Outcome and prognostic factors in the conservative treatment of breast cancer]

The aim of this retrospective study is to evaluate the results and identify prognostic factors in early breast cancer. One hundred breast cancers, 79 stage I and 21 stage II, had a conservative treatment between September 1993 and February 1996. Median age was 57 years; median tumor size 15 mm. Pathology was infiltrating ductal carcinoma in 88%. All patients underwent a conservative surgery followed by external radiotherapy. Twenty-eight patients received adjuvant chemotherapy and 64 patients received hormonal therapy. The median follow-up was 100 months. The 10 years overall survival rate was 85% and the metastasis free survival rate was 88.5%. The 10 years local control rate was 85.7%. Women less than 45 years old had a worse prognosis. These high rates of survival and local control confirm that breast conservation therapy yields favorable results, and that age is a major risk factor in women with early breast cancer

Evaluation de la toxicite aigue chez 50 patients atteints de cancer de la prostate traites par radiotherapie conformationnelle

Purpose: To report our experience with 3D conformal radiotherapy for prostate cancer material and methods: We reviewed our first 50 patients diagnosed with prostate cancer. Median follow-up was 27 months [16-40 m]. Median age 68 [52-74] T stage was T1c = 12 T2a = 14 T2b = 10 T2c = 2 T3a = 10 T3b = 1 and T3c = 1. Gleason score [GS] 4-6 50% and GS 7-8 50%. Pretreatment PSA.value of < 10 ng/ml 36%, 10-20 ng/ml 32% and >20 ng/ml 32%. Forty patients received androgen ablation therapy 2 to 6 months before radiation. 3D conformal radiotherapy was used to allow a smaller amount of rectum and bladder to be in the high dose volume. An 18 Mv linear accelerator was used. The first 21 patients received 66 Gy, 28 patients received 70 Gy and one 74 Gy.The mean prostate volume was 45 cc for patients who received androgen ablation and 54 for the others [p = 0.02]. The percentage of volume receiving more than 50 Gy [V50] was calculated for the rectum and bladder. The median V50 was 30% [10-55] for the rectum and 36% [5-70] for the bladder. Based on the RTOG grading [gr] for acute toxicity, there was no gr 3 gastrointestinal [GI] toxicity and only 1 gr 3 genitourinary [GU] toxicity. There were 9 gr 1 and 5 gr 2 GI toxicity, 10 gr 1 and 5 gr 2 GU toxicity. With our actual follow-up we have 2 late morbidities: gr 2 GLI and one erectile failure.3D conformal radiotherapy for prostate cancer has a good toxicity profile. Longer follow-up is needed to assess late toxicity and clinical outcome in this series